Skip Navigation


Rheumatology Advance Access originally published online on August 31, 2009
Rheumatology 2009 48(11):1359-1362; doi:10.1093/rheumatology/kep260
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
48/11/1359    most recent
kep260v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Lee, Y. H.
Right arrow Articles by Song, G. G.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lee, Y. H.
Right arrow Articles by Song, G. G.
Related Collections
Right arrow Spondylarthropathies
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Lack of association of TNF-{alpha} promoter polymorphisms with ankylosing spondylitis: a meta-analysis

Young H. Lee1 and Gwan G. Song1

1Department of Internal Medicine, Division of Rheumatology, Korea University Medical Center, Korea University College of Medicine, Seoul, Korea.

Correspondence to: Young Ho Lee, Department of Internal Medicine, Division of Rheumatology, Korea University Anam Hospital, Korea University College of Medicine, 126-1 5-ga, Anam-dong, Seongbuk-gu, Seoul 136-705, Korea. E-mail: lyhcgh{at}korea.ac.kr


  Abstract

Objectives. Genetic factors, in addition to the HLA-B27, could play a role in the pathogenesis of AS. TNF-{alpha} promoter polymorphisms have been reported to be associated with AS susceptibility, but the results of these previous studies have been inconsistent. The aim of this study was to explore whether TNF-{alpha} promoter polymorphisms confer susceptibility to AS.

Methods. We conducted a random effect meta-analysis on the association of the A/A genotype (the recessive effect), the A/A + A/G genotype (the dominant effect) and the A allele of the TNF-{alpha} –308 and –238 polymorphisms with AS.

Results. Eight studies, consisting of seven European studies and one Latin American study, were included in this meta-analysis. Any association between AS and the TNF-{alpha} –308 A allele was not found [odds ratio (OR) = 0.911; 95% CI 0.512, 1.286; P = 0.636; I2 = 73.8]. There was also no association of the TNF-{alpha} –308 AA and AA+AG genotypes with AS. Meta-analysis of the TNF-{alpha} –238 polymorphisms showed no association with AS (OR for A allele = 0.930; 95% CI 0.498, 1.737; P = 0.821; I2 = 71.6). Subgroup analysis by ethnicity and HLA-B27 positivity did not change the results for the association of the TNF-{alpha} –308 and –238 polymorphisms with AS.

Conclusions. This meta-analysis including 2247 subjects has shown that there is a lack of association of the TNF-{alpha} –308 A/G and –238 A/G polymorphisms with AS.

KEY WORDS: Ankylosing spondylitis, TNF-{alpha}, Polymorphism, Meta-analysis

Submitted 16 April 2009; Accepted 22 July 2009


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.